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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:135323
Term: gestodene
Definition: null
Chemical ID: MESH:C033273
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein] which results in decreased metabolism of tizanidine; [Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein; Gestodene inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]PMID:16198659 PMID:9305587
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