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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:10588
Term: 1-(3-chlorophenyl)piperazine
Definition: A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
Chemical ID: MESH:C015068
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2aaffects response to substanceISOHTR2A (Homo sapiens)6480464CTDHTR2A protein affects the susceptibility to 1-(3-chlorophenyl)piperazinePMID:16314884
Htr2aincreases response to substanceISOHTR2A (Homo sapiens)6480464CTDHTR2A gene SNP results in increased susceptibility to 1-(3-chlorophenyl)piperazinePMID:16314884
Htr2amultiple interactionsISOHTR2A (Homo sapiens)6480464CTD1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2A proteinPMID:16314884
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