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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:10432
Term: 2-naphthol
Definition: A naphthol carrying a hydroxy group at position 2.
Chemical ID: MESH:C028405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects bindingISOCYP1A2 (Homo sapiens)6480464CTD2-naphthol binds to CYP1A2 proteinPMID:32278787
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTD2-naphthol results in decreased activity of CYP1A2 proteinPMID:15916432
Cyp1a2increases abundanceISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased abundance of 2-naphtholPMID:16243959
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