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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621535
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna1f
Name: calcium voltage-gated channel subunit alpha1 F
Acc ID: CHEBI:101278
Term: diltiazem
Definition: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.
Chemical ID: MESH:D004110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna1fmultiple interactionsISOCacna1f (Mus musculus)6480464CTDDiltiazem inhibits the reaction [CACNA1F protein results in increased transport of Barium]PMID:14744918
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