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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3224
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a1
Name: solute carrier family 22 member 1
Acc ID: CHEBI:101278
Term: diltiazem
Definition: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.
Chemical ID: MESH:D004110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a1multiple interactionsISOSLC22A1 (Homo sapiens)6480464CTDDiltiazem inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]PMID:21641380
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