GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Alox5 | decreases activity | EXP | | 6480464 | CTD | zileuton results in decreased activity of ALOX5 protein | PMID:10694244 PMID:14726295 PMID:17113579 PMID:18295198 PMID:18475545 PMID:7665580 PMID:7922131 PMID:8058773 PMID:9223651 PMID:9445378 PMID:9599246 | Alox5 | decreases expression | EXP | | 6480464 | CTD | zileuton results in decreased expression of ALOX5 mRNA | PMID:19309543 | Alox5 | multiple interactions | EXP | | 6480464 | CTD | [[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; zileuton binds to and results in decreased activity of ALOX5 protein; zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4]; zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]; zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein]; zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ALOX5 protein]; zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein] | PMID:10694244 PMID:11529688 PMID:11561080 PMID:12388339 PMID:12649539 PMID:12654629 PMID:15326064 PMID:18475545 PMID:9223651 | Alox5 | affects response to substance | ISO | ALOX5 (Homo sapiens) | 6480464 | CTD | ALOX5 gene SNP affects the susceptibility to zileuton | PMID:19214143 | Alox5 | decreases activity | ISO | Alox5 (Mus musculus) | 6480464 | CTD | zileuton results in decreased activity of ALOX5 protein | PMID:11694324 PMID:11886531 PMID:12794006 PMID:15266012 PMID:15328337 PMID:15935457 PMID:7812673 PMID:7990266 PMID:8186192 PMID:9593866 | Alox5 | decreases activity | ISO | ALOX5 (Homo sapiens) | 6480464 | CTD | zileuton results in decreased activity of ALOX5 protein | PMID:10377029 PMID:10698703 PMID:10764316 PMID:10852428 PMID:11286996 PMID:12629151 PMID:15501964 PMID:1781415 PMID:18295198 PMID:7592874 PMID:7929400 PMID:8111568 PMID:8113982 PMID:8387780 PMID:8621850 PMID:8666909 PMID:9113110 PMID:9495842 PMID:9850156 | Alox5 | multiple interactions | ISO | Alox5 (Mus musculus) | 6480464 | CTD | [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS1; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]; zileuton inhibits the reaction [Ovalbumin results in increased expression of ALOX5 mRNA] | PMID:11694324 PMID:12794006 PMID:9593866 | Alox5 | multiple interactions | ISO | ALOX5 (Homo sapiens) | 6480464 | CTD | [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]; [zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]; zileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [L 708714 binds to ALOX5 protein] | PMID:10698703 PMID:10764316 PMID:11286996 PMID:15501964 PMID:1781415 PMID:18295198 PMID:7577949 PMID:7592874 PMID:8387780 PMID:8621850 PMID:9495842 PMID:9609743 | | ||||||||||||||||||||||
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