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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1affects expressionEXP 6480464CTDZearalenone affects the expression of ABCC1 mRNA; Zearalenone affects the expression of ABCC1 proteinPMID:22521637
Abcc1decreases expressionEXP 6480464CTDZearalenone results in decreased expression of ABCC1 mRNA; Zearalenone results in decreased expression of ABCC1 proteinPMID:23707492
Abcc1increases expressionISOABCC1 (Homo sapiens)6480464CTDZearalenone results in increased expression of ABCC1 proteinPMID:19580841
Abcc1increases transportISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in increased transport of ZearalenonePMID:19647055
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTDverlukast inhibits the reaction [ABCC1 protein results in increased transport of Zearalenone]; Zearalenone inhibits the reaction [ABCC1 protein results in increased transport of calcein AM]PMID:19647055
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