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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2469
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c11
Name: cytochrome P450, subfamily 2, polypeptide 11
Acc ID: CHEBI:10033
Term: warfarin
Definition: A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.
Chemical ID: MESH:D014859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c11increases metabolic processingEXP 6480464CTDCYP2C11 protein results in increased metabolism of WarfarinPMID:30724651
Cyp2c11affects response to substanceISOCYP2C18 (Homo sapiens)6480464CTDCYP2C18 gene polymorphism affects the susceptibility to Warfarin; CYP2C18 protein affects the susceptibility to WarfarinPMID:19752777
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