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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:100246
Term: norfloxacin
Definition: A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Chemical ID: MESH:D009643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects bindingEXP 6480464CTDNorfloxacin binds to CYP1A2 proteinPMID:8905919
Cyp1a2multiple interactionsEXP 6480464CTDNorfloxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]PMID:8905919
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