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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp1a2 Name: cytochrome P450, family 1, subfamily a, polypeptide 2

Acc ID: CHEBI:100241 Term: ciprofloxacin Definition: Quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively. CasRN: 85721-33-1 Chemical ID: MESH:D002939

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:735711	6480464	CTD	Ciprofloxacin results in decreased activity of CYP1A2 protein	PMID:18816299 PMID:11145498 PMID:15592331
multiple interactions	ISO	RGD:735711	6480464	CTD	Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]	PMID:15592331
decreases activity	ISO	RGD:735711	6480464	CTD	Ciprofloxacin results in decreased activity of CYP1A2 protein	PMID:15592331 PMID:11145498 PMID:18816299
multiple interactions	ISO	RGD:735711	6480464	CTD	Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]	PMID:11145498
multiple interactions	ISO	RGD:735711	6480464	CTD	[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of norclozapine	PMID:11151749
decreases activity	ISO	RGD:735711	6480464	CTD	Ciprofloxacin results in decreased activity of CYP1A2 protein	PMID:11145498 PMID:18816299 PMID:15592331
decreases activity	ISO	RGD:735711	6480464	CTD	Ciprofloxacin results in decreased activity of CYP1A2 protein	PMID:18816299 PMID:15592331 PMID:11145498
decreases activity	ISO	RGD:735711	6480464	CTD	Ciprofloxacin results in decreased activity of CYP1A2 protein	PMID:11145498 PMID:15592331 PMID:18816299