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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases activityISOPPARG (Homo sapiens)6480464CTDdeoxynivalenol results in decreased activity of PPARG proteinPMID:27481073
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDdeoxynivalenol results in increased expression of PPARG mRNAPMID:18485432
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTD15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [deoxynivalenol results in increased expression of PPARG protein]; EGR1 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]; lipopolysaccharide, E coli O55-B5 affects the reaction [deoxynivalenol results in increased expression of PPARG mRNA]; MAPK1 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]; MAPK3 protein promotes the reaction [deoxynivalenol results in increased expression of PPARG mRNA]; PPARG protein affects the reaction [deoxynivalenol results in decreased degradation of CXCL8 mRNA]; U 0126 inhibits the reaction [deoxynivalenol results in increased expression of PPARG mRNA]PMID:18485432
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