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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305476
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mki67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mki67increases expressionISOMKI67 (Homo sapiens)6480464CTDdeoxynivalenol results in increased expression of MKI67 mRNAPMID:31863870
Mki67increases expressionISOMki67 (Mus musculus)6480464CTDdeoxynivalenol results in increased expression of MKI67 proteinPMID:32416088
Mki67increases phosphorylationISOMki67 (Mus musculus)6480464CTDdeoxynivalenol results in increased phosphorylation of MKI67 proteinPMID:23352502 PMID:23811945
Mki67multiple interactionsISOMki67 (Mus musculus)6480464CTDCelecoxib inhibits the reaction [deoxynivalenol results in increased expression of MKI67 protein]PMID:32416088
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