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GENE - TERM ANNOTATION REPORT

RGD ID: 737466 Species: Mus musculus RGD Object: Gene Symbol: Ctla4 Name: cytotoxic T-lymphocyte-associated protein 4

Acc ID: RDO:0004489 Term: Liver Cirrhosis, Biliary Definition: FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Susceptibility	ISS	RGD:737465	2301998	RGD	autoimmune biliary cirrhosis DNA:SNP:CDS:49A>G, significant association with G allele (p<0.0002) (human)