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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737063 Species: Mus musculus RGD Object: Gene Symbol: Prkca Name: protein kinase C, alpha

Acc ID: CHEBI:34873 Term: N-nitrosodiethylamine Definition: A nitrosamine that has formula C4H10N2O. CasRN: 55-18-5 Chemical ID: MESH:D004052

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCA protein MET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCA protein]	PMID:17942915
multiple interactions	ISO	RGD:3395	6480464	CTD	bicyclol inhibits the reaction [Diethylnitrosamine results in increased expression of PRKCA mRNA]	PMID:17106253
increases expression	ISO	RGD:3395	6480464	CTD	Diethylnitrosamine results in increased expression of PRKCA mRNA	PMID:17106253