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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737024 Species: Homo sapiens RGD Object: Gene Symbol: MUC5AC Name: mucin 5AC, oligomeric mucus/gel-forming

Acc ID: CHEBI:15368 Term: acrolein Definition: An enal that has formula C3H4O. CasRN: 107-02-8 Chemical ID: MESH:D000171

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Acrolein results in increased expression of MUC5AC mRNA	PMID:15531749 PMID:19661247
multiple interactions	EXP		6480464	CTD	ADAM17 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA] GM 6001 inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA] EGFR protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA] MMP9 protein promotes the reaction [Acrolein results in increased expression of MUC5AC mRNA] PD 98059 inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA] TIMP3 protein inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	PMID:15531749
multiple interactions	EXP		6480464	CTD	MMP14 protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA]	PMID:19661247
increases expression	ISO	RGD:62293	6480464	CTD	Acrolein results in increased expression of MUC5AC mRNA	PMID:18006877 PMID:19661247
multiple interactions	ISO	RGD:62293	6480464	CTD	erlotinib inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	PMID:19661247 PMID:18006877
multiple interactions	ISO	RGD:62293	6480464	CTD	MMP9 gene mutant form inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	PMID:18006877
increases expression	EXP		6480464	CTD	Acrolein results in increased expression of MUC5AC protein	PMID:20359552
increases expression	EXP		6480464	CTD	Acrolein results in increased expression of MUC5AC mRNA	PMID:19661247 PMID:15531749
multiple interactions	EXP		6480464	CTD	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]]	PMID:20359552
increases expression	ISO	RGD:62001	6480464	CTD	Acrolein results in increased expression of MUC5AC protein Acrolein results in increased expression of MUC5AC mRNA	PMID:19464576 PMID:20359552
multiple interactions	ISO	RGD:62001	6480464	CTD	rosiglitazone inhibits the reaction [Acrolein results in increased expression of MUC5AC protein] rosiglitazone inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	PMID:19464576
multiple interactions	ISO	RGD:62001	6480464	CTD	Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA] Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]	PMID:20359552
increases expression	ISO	RGD:62293	6480464	CTD	Acrolein results in increased expression of MUC5AC mRNA	PMID:19661247 PMID:18006877
multiple interactions	ISO	RGD:62293	6480464	CTD	erlotinib inhibits the reaction [Acrolein results in increased expression of MUC5AC mRNA]	PMID:18006877 PMID:19661247
increases expression	ISO	RGD:62001	6480464	CTD	Acrolein results in increased expression of MUC5AC mRNA Acrolein results in increased expression of MUC5AC protein	PMID:20359552 PMID:19464576