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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736886 Species: Homo sapiens RGD Object: Gene Symbol: HPGD Name: hydroxyprostaglandin dehydrogenase 15-(NAD)

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of HPGD mRNA	PMID:19619570
multiple interactions	EXP		6480464	CTD	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of HPGD mRNA	PMID:19619570
multiple interactions	ISO	RGD:736887	6480464	CTD	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of HPGD mRNA	PMID:16214954
multiple interactions	ISO	RGD:736887	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HPGD mRNA	PMID:17942748
increases expression	ISO	RGD:736887	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HPGD mRNA	PMID:15328365 PMID:18796159
increases expression	ISO	RGD:736887	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HPGD mRNA	PMID:18796159 PMID:19770486 PMID:15328365
increases expression	ISO	RGD:736887	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HPGD mRNA	PMID:15328365 PMID:19770486 PMID:18796159
increases expression	ISO	RGD:736887	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HPGD mRNA	PMID:19770486 PMID:18796159 PMID:15328365
increases expression	ISO	RGD:736887	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HPGD mRNA	PMID:19770486 PMID:15328365 PMID:18796159
decreases expression	ISO	RGD:736887	6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of HPGD protein	PMID:21653731
multiple interactions	ISO	RGD:736887	6480464	CTD	Fish Oils inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HPGD protein]	PMID:21653731
increases expression	ISO	RGD:736887	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of HPGD mRNA	PMID:15328365 PMID:18796159 PMID:19770486
affects expression	ISO	RGD:736887	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of HPGD mRNA	PMID:21570461