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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736368 Species: Mus musculus RGD Object: Gene Symbol: Pdx1 Name: pancreatic and duodenal homeobox 1

Acc ID: CHEBI:17234 Term: glucose Definition: null CasRN: 50-99-7 Chemical ID: MESH:D005947

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects localization	ISO	RGD:736367	6480464	CTD	Glucose affects the localization of PDX1 protein	PMID:11574405
multiple interactions	EXP		6480464	CTD	calyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein] [Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein Okadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein] [Glucose co-treated with INS1 protein] affects the localization of PDX1 protein SB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein] wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein] SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]	PMID:11574405
affects localization	EXP		6480464	CTD	Glucose affects the localization of PDX1 protein	PMID:11574405
multiple interactions	ISO	RGD:736367	6480464	CTD	calyculin A inhibits the reaction [Glucose affects the localization of PDX1 protein] Okadaic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein] [Glucose co-treated with INS protein] affects the localization of PDX1 protein [SB 203580 co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein] [Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein SB 203580 inhibits the reaction [Glucose affects the localization of PDX1 protein] wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein] [wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein] SB 203580 inhibits the reaction [[Glucose co-treated with sodium arsenite] affects the localization of PDX1 protein]	PMID:11574405
increases activity	EXP		6480464	CTD	Glucose results in increased activity of PDX1 promoter	PMID:16489446
multiple interactions	EXP		6480464	CTD	[Metformin co-treated with Glucose] affects the localization of PDX1 protein rosiglitazone promotes the reaction [Glucose results in increased activity of PDX1 promoter]	PMID:16489446
affects localization	ISO	RGD:736367	6480464	CTD	Glucose affects the localization of PDX1 protein	PMID:11574405 PMID:22558381
multiple interactions	ISO	RGD:736367	6480464	CTD	Palmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein]	PMID:22558381
multiple interactions	EXP		6480464	CTD	IL1B protein inhibits the reaction [Glucose results in increased expression of PDX1 mRNA] lipopolysaccharide, Escherichia coli 0111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA] TLR4 affects the reaction [lipopolysaccharide, Escherichia coli 0111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]] Palmitic Acid inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]	PMID:22558381
increases expression	EXP		6480464	CTD	Glucose results in increased expression of PDX1 mRNA	PMID:22558381
increases expression	ISO	RGD:62387	6480464	CTD	Glucose results in increased expression of PDX1 mRNA	PMID:22558381
multiple interactions	ISO	RGD:62387	6480464	CTD	lipopolysaccharide, Escherichia coli 0111 B4 inhibits the reaction [Glucose results in increased expression of PDX1 mRNA]	PMID:22558381