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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736366 Species: Homo sapiens RGD Object: Gene Symbol: REN Name: renin

Acc ID: CHEBI:7565 Term: nifedipine Definition: A dihydropyridine that has formula C17H18N2O6. CasRN: 21829-25-4 Chemical ID: MESH:D009543

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	PMID:3142437
multiple interactions	EXP		6480464	CTD	Angiotensin-Converting Enzyme Inhibitors promotes the reaction [Nifedipine results in increased activity of REN protein] Nifedipine promotes the reaction [Angiotensin-Converting Enzyme Inhibitors results in increased activity of REN protein]	PMID:3326920
increases activity	EXP		6480464	CTD	Nifedipine results in increased activity of REN protein	PMID:6184561 PMID:6354932 PMID:3326920
increases expression	EXP		6480464	CTD	Nifedipine results in increased expression of REN protein	PMID:3313686
increases activity	EXP		6480464	CTD	Nifedipine results in increased activity of REN protein	PMID:3326920 PMID:6184561 PMID:6354932
increases activity	EXP		6480464	CTD	Nifedipine results in increased activity of REN protein	PMID:6354932 PMID:3326920 PMID:6184561
increases activity	EXP		6480464	CTD	Nifedipine results in increased activity of REN protein	PMID:6354932 PMID:6184561 PMID:3326920