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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736366 Species: Homo sapiens RGD Object: Gene Symbol: REN Name: renin

Acc ID: CHEBI:2904 Term: atenolol Definition: An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. CasRN: 29122-68-7 Chemical ID: MESH:D001262

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[aliskiren co-treated with Atenolol] results in decreased activity of REN protein	PMID:18957387
decreases activity	EXP		6480464	CTD	Atenolol results in decreased activity of REN protein	PMID:18957387 PMID:3333524
decreases expression	EXP		6480464	CTD	Atenolol results in decreased expression of REN protein	PMID:14639093
multiple interactions	EXP		6480464	CTD	[Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein	PMID:3142437
multiple interactions	ISO	RGD:3554	6480464	CTD	Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein] Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]	PMID:9300315
decreases expression	ISO	RGD:3554	6480464	CTD	Atenolol results in decreased expression of REN protein	PMID:9300315
decreases activity	EXP		6480464	CTD	Atenolol results in decreased activity of REN protein	PMID:3333524 PMID:18957387