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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736362 Species: Mus musculus RGD Object: Gene Symbol: Prkcz Name: protein kinase C, zeta

Acc ID: CHEBI:18406 Term: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Definition: A 1-(phosphoribosyl)imidazolecarboxamide that has formula C9H15N4O8P. CasRN: 3031-94-5 Chemical ID: MESH:C031143

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:3399	6480464	CTD	1-Butanol inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] GRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] Genistein inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] PTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein] PD 98059 inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]	PMID:11978788
increases activity	ISO	RGD:3399	6480464	CTD	AICA ribonucleotide results in increased activity of PRKCZ protein	PMID:11978788