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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736306 Species: Homo sapiens RGD Object: Gene Symbol: IL4 Name: interleukin 4

Acc ID: CHEBI:9150 Term: simvastatin Definition: A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. CasRN: 79902-63-9 Chemical ID: MESH:D019821

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	IL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA] IL4 affects the reaction [Simvastatin results in decreased secretion of IL17A protein] IL4 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]	PMID:18453621
increases expression	EXP		6480464	CTD	Simvastatin results in increased expression of IL4 mRNA	PMID:18453621
increases secretion	EXP		6480464	CTD	Simvastatin results in increased secretion of IL4 protein	PMID:18453621
decreases expression	ISO	RGD:10796	6480464	CTD	Simvastatin results in decreased expression of IL4 mRNA Simvastatin results in decreased expression of IL4 protein	PMID:17169357