• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736205 Species: Mus musculus RGD Object: Gene Symbol: Irs2 Name: insulin receptor substrate 2

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736204	6480464	CTD	Estradiol promotes the reaction [Progesterone results in increased expression of IRS2 mRNA] Estradiol promotes the reaction [Progesterone results in increased expression of IRS2 protein] Estradiol promotes the reaction [Progesterone results in increased phosphorylation of IRS2 protein]	PMID:15949379
increases expression	ISO	RGD:736204	6480464	CTD	Estradiol results in increased expression of IRS2 mRNA Estradiol results in increased expression of IRS2 protein	PMID:15949379
increases phosphorylation	ISO	RGD:736204	6480464	CTD	Estradiol results in increased phosphorylation of IRS2 protein	PMID:15949379
multiple interactions	ISO	RGD:736204	6480464	CTD	[Progesterone co-treated with Estradiol] results in increased expression of IRS2 mRNA	PMID:17404688
decreases expression	ISO	RGD:736204	6480464	CTD	Estradiol results in decreased expression of IRS2 mRNA	PMID:19167446