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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736157 Species: Homo sapiens RGD Object: Gene Symbol: ABCA1 Name: ATP-binding cassette, sub-family A (ABC1), member 1

Acc ID: CHEBI:34247 Term: 2,6-di-tert-butyl-4-methylphenol Definition: A phenol that has formula C15H24O. CasRN: 128-37-0 Chemical ID: MESH:D002084

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 protein Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA] Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]	PMID:17070507
increases expression	EXP		6480464	CTD	Butylated Hydroxytoluene results in increased expression of ABCA1 mRNA	PMID:17070507