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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736066 Species: Homo sapiens RGD Object: Gene Symbol: SPP1 Name: secreted phosphoprotein 1

Acc ID: CHEBI:4653 Term: dipyridamole Definition: A pyrimidopyrimidine that has formula C24H40N8O4. CasRN: 58-32-2 Chemical ID: MESH:D004176

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:3752	6480464	CTD	Dinitrochlorobenzene inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] Dipyridamole inhibits the reaction [Glucose results in increased expression of SPP1 mRNA] KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]	PMID:20453393
multiple interactions	ISO	RGD:3752	6480464	CTD	Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]] tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]	PMID:19356721