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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868 Species: Homo sapiens RGD Object: Gene Symbol: NQO1 Name: NAD(P)H dehydrogenase, quinone 1

Acc ID: CHEBI:25195 Term: mercury atom Definition: A zinc group element atom that has formula Hg. CasRN: 7439-97-6 Chemical ID: MESH:D008628

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10473	6480464	CTD	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]] Dactinomycin inhibits the reaction [Mercury results in increased expression of NQO1 mRNA] Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein] Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA] NFE2L2 protein affects the reaction [Mercury results in increased expression of NQO1 mRNA]	PMID:16243960
increases activity	ISO	RGD:10473	6480464	CTD	Mercury results in increased activity of NQO1 protein	PMID:16243960
increases expression	ISO	RGD:10473	6480464	CTD	Mercury results in increased expression of NQO1 mRNA	PMID:16243960
multiple interactions	ISO	RGD:10473	6480464	CTD	Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 protein] Mercury results in increased expression of and results in increased activity of NQO1 protein	PMID:22579925
multiple interactions	ISO	RGD:10473	6480464	CTD	Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]	PMID:22579925 PMID:16243960
increases expression	ISO	RGD:10473	6480464	CTD	Mercury results in increased expression of NQO1 mRNA	PMID:22579925 PMID:16243960
increases expression	ISO	RGD:10473	6480464	CTD	Mercury results in increased expression of NQO1 mRNA	PMID:16243960 PMID:18752316 PMID:22579925
increases expression	ISO	RGD:10473	6480464	CTD	Mercury results in increased expression of NQO1 protein	PMID:18752316
multiple interactions	ISO	RGD:10473	6480464	CTD	anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Mercury results in increased expression of NQO1 mRNA] Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 mRNA] anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Mercury results in increased expression of NQO1 protein] Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 protein] prolinedithiocarbamate promotes the reaction [Mercury results in increased expression of NQO1 protein] Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 protein] Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 mRNA] U 0126 promotes the reaction [Mercury results in increased expression of NQO1 mRNA] U 0126 promotes the reaction [Mercury results in increased expression of NQO1 protein]	PMID:18752316
multiple interactions	ISO	RGD:10473	6480464	CTD	Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]	PMID:16243960 PMID:22579925