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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735779 Species: Homo sapiens RGD Object: Gene Symbol: DIO2 Name: deiodinase, iodothyronine, type II

Acc ID: CHEBI:52722 Term: lactacystin Definition: L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group. CasRN: 133343-34-7 Chemical ID: MESH:C067713

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	lactacystin inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein] lactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein] lactacystin results in increased expression of and results in increased activity of DIO2 protein	PMID:11425850