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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711 Species: Homo sapiens RGD Object: Gene Symbol: CYP1A2 Name: cytochrome P450, family 1, subfamily A, polypeptide 2

Acc ID: CHEBI:34591 Term: bromodichloromethane Definition: A halomethane that has formula CHBrCl2. CasRN: 75-27-4 Chemical ID: MESH:C025191

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases metabolic processing	EXP		6480464	CTD	CYP1A2 protein results in increased metabolism of bromodichloromethane	PMID:12076521
decreases expression	ISO	RGD:2459	6480464	CTD	bromodichloromethane results in decreased expression of CYP1A2 protein	PMID:11295256
increases expression	ISO	RGD:2459	6480464	CTD	bromodichloromethane results in increased expression of CYP1A2 protein	PMID:11295256
affects metabolic processing	ISO	RGD:2459	6480464	CTD	CYP1A2 protein affects the metabolism of bromodichloromethane	PMID:12062927
multiple interactions	ISO	RGD:2459	6480464	CTD	isosafrole inhibits the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane] Tetrachlorodibenzodioxin promotes the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane]	PMID:12062927
increases metabolic processing	ISO	RGD:2459	6480464	CTD	CYP1A2 protein results in increased metabolism of bromodichloromethane	PMID:12076521 PMID:11295256
increases metabolic processing	ISO	RGD:2459	6480464	CTD	CYP1A2 protein results in increased metabolism of bromodichloromethane	PMID:11295256 PMID:12076521