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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735621 Species: Homo sapiens RGD Object: Gene Symbol: CXCL2 Name: chemokine (C-X-C motif) ligand 2

Acc ID: CHEBI:3962 Term: curcumin Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. CasRN: 458-37-7 Chemical ID: MESH:D003474

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Curcumin results in decreased expression of CXCL2 protein Curcumin results in decreased expression of CXCL2 mRNA	PMID:17999991
multiple interactions	EXP		6480464	CTD	NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]	PMID:17999991
multiple interactions	ISO	RGD:733118	6480464	CTD	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA]	PMID:18200517
multiple interactions	ISO	RGD:70069	6480464	CTD	Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]	PMID:18001810