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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735440 Species: Homo sapiens RGD Object: Gene Symbol: NFKBIA Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Acc ID: CHEBI:30185 Term: zinc(0) Definition: An elemental zinc that has formula Zn. CasRN: 7440-66-6 Chemical ID: MESH:D015032

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Zinc inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]	PMID:16606632
multiple interactions	EXP		6480464	CTD	Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein] [Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of BCL2 protein [Zinc results in increased localization of [IKBKB protein binds to NFKBIA protein]] which results in increased expression of NFKB1 protein	PMID:17029595
multiple interactions	EXP		6480464	CTD	Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased degradation of NFKBIA protein]	PMID:18615482