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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735269 Species: Homo sapiens RGD Object: Gene Symbol: DIO1 Name: deiodinase, iodothyronine, type I

Acc ID: CHEBI:28774 Term: 3,3',5'-triiodothyronine Definition: An iodothyronine that has formula C15H12I3NO4. CasRN: 5817-39-0 Chemical ID: MESH:D014285

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine Iodoacetates inhibits the reaction [[DIO1 protein results in increased metabolism of Triiodothyronine, Reverse] which results in increased abundance of 3,3'-diiodothyronine]	PMID:21565810
increases metabolic processing	EXP		6480464	CTD	DIO1 protein results in increased metabolism of Triiodothyronine, Reverse	PMID:21565810