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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734049 Species: Homo sapiens RGD Object: Gene Symbol: COL1A1 Name: collagen, type I, alpha 1

Acc ID: CHEBI:15379 Term: dioxygen Definition: An elemental molecule that has formula O2. CasRN: 7782-44-7 Chemical ID: MESH:D010100

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:61817	6480464	CTD	[Paraquat co-treated with Oxygen] results in increased expression of COL1A1 mRNA	PMID:12882763
increases expression	ISO	RGD:61817	6480464	CTD	Oxygen deficiency results in increased expression of COL1A1 mRNA Oxygen deficiency results in increased expression of COL1A1 protein	PMID:11981751
multiple interactions	EXP		6480464	CTD	Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA] exoenzyme C3, Clostridium botulinum inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA]	PMID:21439370
increases expression	ISO	RGD:62109	6480464	CTD	Oxygen results in increased expression of COL1A1 mRNA	PMID:21439370 PMID:22363622
multiple interactions	ISO	RGD:62109	6480464	CTD	Y 27632 inhibits the reaction [Oxygen results in increased expression of COL1A1 mRNA]	PMID:21439370
increases expression	EXP		6480464	CTD	Oxygen results in increased expression of COL1A1 mRNA	PMID:21439370