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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733809 Species: Homo sapiens RGD Object: Gene Symbol: SLC6A3 Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Acc ID: CHEBI:33216 Term: bisphenol A Definition: A bisphenol that has formula C15H16O2. CasRN: 80-05-7 Chemical ID: MESH:C006780

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects localization	ISO	RGD:3715	6480464	CTD	bisphenol A affects the localization of SLC6A3 protein	PMID:19479021
multiple interactions	ISO	RGD:3715	6480464	CTD	bisphenol A affects the reaction [SLC6A3 protein affects the export of Dopamine] [bisphenol A co-treated with Estradiol] inhibits the reaction [SLC6A3 protein affects the export of Dopamine]	PMID:19479021
decreases expression	ISO	RGD:3715	6480464	CTD	bisphenol A results in decreased expression of SLC6A3 mRNA	PMID:15079872 PMID:17689037
decreases expression	ISO	RGD:3715	6480464	CTD	bisphenol A results in decreased expression of SLC6A3 mRNA	PMID:17689037 PMID:15079872