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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733702
Species: Homo sapiens
RGD Object: Gene
Symbol: CACNA1E
Name: calcium voltage-gated channel subunit alpha1 E
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CACNA1Edecreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of CACNA1E genePMID:31601247
CACNA1Eincreases expressionEXP 6480464CTDbisphenol A results in increased expression of CACNA1E mRNAPMID:29275510
CACNA1Emultiple interactionsEXP 6480464CTDbisphenol A promotes the reaction [Estradiol results in decreased activity of [CACNA1E protein binds to CACNB3 protein]]; bisphenol A results in decreased activity of [CACNA1E protein binds to CACNB3 protein]; Estradiol promotes the reaction [bisphenol A results in decreased activity of [CACNA1E protein binds to CACNB3 protein]]PMID:23197648
CACNA1Eaffects expressionISOCacna1e (Rattus norvegicus)6480464CTDbisphenol A affects the expression of CACNA1E mRNAPMID:25181051 PMID:30816183
CACNA1Edecreases expressionISOCacna1e (Mus musculus)6480464CTDbisphenol A results in decreased expression of CACNA1E mRNAPMID:32156529
CACNA1Eincreases expressionISOCacna1e (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of CACNA1E mRNAPMID:29097150
CACNA1Emultiple interactionsISOCacna1e (Rattus norvegicus)6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of CACNA1E mRNAPMID:25607892
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