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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733456
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNMB1
Name: potassium calcium-activated channel subfamily M regulatory beta subunit 1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNMB1affects bindingEXP 6480464CTDLithocholic Acid binds to KCNMB1 proteinPMID:22123969
KCNMB1increases activityEXP 6480464CTDLithocholic Acid analog results in increased activity of KCNMB1 protein; Lithocholic Acid results in increased activity of KCNMB1 proteinPMID:22945504
KCNMB1multiple interactionsEXP 6480464CTD[KCNMB1 protein co-treated with KCNMA1 protein] results in increased susceptibility to Lithocholic Acid; Lithocholic Acid promotes the reaction [[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]PMID:22123969
KCNMB1increases response to substanceISOKcnmb1 (Rattus norvegicus)6480464CTDKCNMB1 protein results in increased susceptibility to Lithocholic AcidPMID:19852931
KCNMB1increases response to substanceISOKcnmb1 (Mus musculus)6480464CTDKCNMB1 protein results in increased susceptibility to Lithocholic AcidPMID:17468198
KCNMB1multiple interactionsISOKcnmb1 (Rattus norvegicus)6480464CTDLithocholic Acid analog results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]PMID:18650555
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