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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733214 Species: Mus musculus RGD Object: Gene Symbol: Tpo Name: thyroid peroxidase

Acc ID: CHEBI:63613 Term: nevirapine Definition: A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection. CasRN: 129618-40-2 Chemical ID: MESH:D019829

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:735786	6480464	CTD	Nevirapine results in increased expression of TPO mRNA Nevirapine results in increased expression of TPO protein	PMID:16030158