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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733197
Species: Homo sapiens
RGD Object: Gene
Symbol: TRPV1
Name: transient receptor potential cation channel subfamily V member 1
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TRPV1multiple interactionsISOTrpv1 (Mus musculus)6480464CTDTRPV1 gene mutant form inhibits the reaction [Capsaicin results in increased abundance of Reactive Oxygen Species]; TRPV1 gene mutant form inhibits the reaction [resiniferatoxin results in increased abundance of Reactive Oxygen Species]; TRPV1 mutant form inhibits the reaction [Capsaicin results in increased abundance of Reactive Oxygen Species]PMID:19531269 PMID:20712533
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