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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733197
Species: Homo sapiens
RGD Object: Gene
Symbol: TRPV1
Name: transient receptor potential cation channel subfamily V member 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TRPV1affects response to substanceISOTrpv1 (Rattus norvegicus)6480464CTDTRPV1 protein affects the susceptibility to NicotinePMID:19483072
TRPV1increases activityISOTrpv1 (Rattus norvegicus)6480464CTDNicotine results in increased activity of TRPV1 proteinPMID:19483072
TRPV1increases expressionISOTrpv1 (Rattus norvegicus)6480464CTDNicotine results in increased expression of TRPV1 mRNA; Nicotine results in increased expression of TRPV1 proteinPMID:26524655
TRPV1multiple interactionsISOTrpv1 (Rattus norvegicus)6480464CTDMecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]PMID:26524655
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