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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733179 Species: Homo sapiens RGD Object: Gene Symbol: CCNB1 Name: cyclin B1

Acc ID: CHEBI:46345 Term: 5-fluorouracil Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. CasRN: 51-21-8 Chemical ID: MESH:D005472

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in decreased expression of CCNB1 protein] TP53 protein inhibits the reaction [N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in decreased expression of CCNB1 protein]] TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of CCNB1 protein]	PMID:15546879
decreases expression	EXP		6480464	CTD	Fluorouracil results in decreased expression of CCNB1 mRNA	PMID:16557594 PMID:17982676 PMID:15205334
decreases expression	EXP		6480464	CTD	Fluorouracil results in decreased expression of CCNB1 protein	PMID:15546879
multiple interactions	EXP		6480464	CTD	TP53 protein affects the reaction [Fluorouracil results in decreased expression of CCNB1 mRNA]	PMID:15016801
multiple interactions	EXP		6480464	CTD	TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of CCNB1 mRNA]	PMID:17982676
decreases expression	EXP		6480464	CTD	Fluorouracil results in decreased expression of CCNB1 mRNA	PMID:17982676 PMID:16557594 PMID:15205334
decreases expression	EXP		6480464	CTD	Fluorouracil results in decreased expression of CCNB1 mRNA	PMID:15205334 PMID:16557594 PMID:17982676
decreases expression	EXP		6480464	CTD	Fluorouracil results in decreased expression of CCNB1 mRNA	PMID:17982676 PMID:15205334 PMID:16557594
decreases expression	EXP		6480464	CTD	Fluorouracil results in decreased expression of CCNB1 mRNA	PMID:15205334 PMID:17982676 PMID:16557594