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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732994 Species: Homo sapiens RGD Object: Gene Symbol: PIK3C3 Name: phosphatidylinositol 3-kinase, catalytic subunit type 3

Acc ID: CHEBI:28940 Term: calciol Definition: A seco-cholestane that has formula C27H44O. CasRN: 67-97-0 Chemical ID: MESH:D002762

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Cholecalciferol promotes the reaction [PIK3C3 protein binds to BECN1 protein] BECN1 mutant form inhibits the reaction [Cholecalciferol promotes the reaction [PIK3C3 protein binds to BECN1 protein]] PIK3C3 mutant form inhibits the reaction [Cholecalciferol promotes the reaction [PIK3C3 protein binds to BECN1 protein]]	PMID:18628207
increases expression	EXP		6480464	CTD	Cholecalciferol results in increased expression of PIK3C3 protein	PMID:18628207
multiple interactions	EXP		6480464	CTD	PIK3C3 mutant form inhibits the reaction [Cholecalciferol promotes the reaction [PIK3C3 protein binds to BECN1 protein]]	PMID:18628207 PMID:18628207