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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732954 Species: Homo sapiens RGD Object: Gene Symbol: DUSP1 Name: dual specificity phosphatase 1

Acc ID: CHEBI:41879 Term: dexamethasone Definition: A fluorinated steroid that has formula C22H29FO5. CasRN: 50-02-2 Chemical ID: MESH:D003907

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Dexamethasone results in increased expression of DUSP1 mRNA	PMID:16144937
multiple interactions	ISO	RGD:732955	6480464	CTD	Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of DUSP1 mRNA] Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of DUSP1 protein] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 mRNA]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 protein]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] DUSP1 gene mutant form promotes the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]] DUSP1 protein promotes the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK14 protein]] DUSP1 protein promotes the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK8 protein]]	PMID:16880258