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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732416 Species: Homo sapiens RGD Object: Gene Symbol: RPE65 Name: retinal pigment epithelium-specific protein 65kDa

Acc ID: CHEBI:17898 Term: all-trans-retinal Definition: A retinal in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 116-31-4 Chemical ID: MESH:D012172

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2319763	6480464	CTD	[13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde	PMID:16411761
increases chemical synthesis	EXP		6480464	CTD	RPE65 protein results in increased chemical synthesis of Retinaldehyde	PMID:16828753
multiple interactions	ISO	RGD:732417	6480464	CTD	[13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde	PMID:16411761
multiple interactions	ISO	RGD:732417	6480464	CTD	Retinaldehyde inhibits the reaction [RPE65 exon mutant form results in decreased uptake of Manganese]	PMID:19060264
increases chemical synthesis	ISO	RGD:732417	6480464	CTD	RPE65 protein results in increased chemical synthesis of Retinaldehyde	PMID:16026160
multiple interactions	ISO	RGD:621396	6480464	CTD	[3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde	PMID:16411761
increases metabolic processing	ISO	RGD:732417	6480464	CTD	RPE65 protein results in increased metabolism of Retinaldehyde	PMID:17251447
multiple interactions	ISO		6480464	CTD	[3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde	PMID:16411761
increases metabolic processing	ISO		6480464	CTD	RPE65 protein results in increased metabolism of Retinaldehyde	PMID:17251447
increases chemical synthesis	ISO		6480464	CTD	RPE65 protein results in increased chemical synthesis of Retinaldehyde	PMID:16026160
multiple interactions	ISO		6480464	CTD	Retinaldehyde inhibits the reaction [RPE65 exon mutant form results in decreased uptake of Manganese]	PMID:19060264