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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732272 Species: Mus musculus RGD Object: Gene Symbol: Mapk8 Name: mitogen-activated protein kinase 8

Acc ID: CHEBI:52289 Term: wortmannin Definition: A delta-lactone that has formula C23H24O8. CasRN: 19545-26-7 Chemical ID: MESH:C009687

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK8 protein] wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK8 protein]	PMID:18950629
decreases phosphorylation	EXP		6480464	CTD	wortmannin results in decreased phosphorylation of MAPK8 protein	PMID:18950629