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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732227 Species: Homo sapiens RGD Object: Gene Symbol: NR3C1 Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Acc ID: CHEBI:17650 Term: cortisol Definition: Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the 'stress hormone' as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses CasRN: 50-23-7 Chemical ID: MESH:D006854

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects binding	EXP		6480464	CTD	Hydrocortisone binds to NR3C1 protein	PMID:11956172 PMID:16857225 PMID:15705660
increases activity	EXP		6480464	CTD	Hydrocortisone results in increased activity of NR3C1 protein	PMID:15780662
multiple interactions	EXP		6480464	CTD	Hydrocortisone binds to and affects the activity of NR3C1 protein	PMID:15883974
multiple interactions	EXP		6480464	CTD	Hydrocortisone binds to and results in increased activity of NR3C1 protein	PMID:11956172
increases phosphorylation	EXP		6480464	CTD	Hydrocortisone results in increased phosphorylation of NR3C1 protein	PMID:18483179
increases expression	EXP		6480464	CTD	Hydrocortisone results in increased expression of NR3C1	PMID:16054388
multiple interactions	EXP		6480464	CTD	NR3C1 protein alternative form inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein alternative form]	PMID:15755863
affects abundance	EXP		6480464	CTD	NR3C1 gene polymorphism affects the abundance of Hydrocortisone	PMID:17716631
multiple interactions	EXP		6480464	CTD	Thiram inhibits the reaction [Hydrocortisone binds to NR3C1 protein]	PMID:16857225
affects binding	EXP		6480464	CTD	Hydrocortisone binds to NR3C1 protein	PMID:16857225 PMID:11956172 PMID:15705660
multiple interactions	EXP		6480464	CTD	2,2',4,4',5-brominated diphenyl ether inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] Mifepristone inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] pentabrominated diphenyl ether 100 inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] Polybrominated Biphenyls metabolite inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein]	PMID:19672399
affects binding	EXP		6480464	CTD	Hydrocortisone binds to NR3C1 protein	PMID:16857225 PMID:15705660 PMID:11956172
increases activity	EXP		6480464	CTD	Hydrocortisone results in increased activity of NR3C1 protein	PMID:19672399 PMID:15780662 PMID:21543282
affects binding	ISO	RGD:10691	6480464	CTD	Hydrocortisone analog binds to NR3C1 protein	PMID:926113
increases activity	EXP		6480464	CTD	Hydrocortisone results in increased activity of NR3C1 protein	PMID:19672399 PMID:21543282 PMID:15780662
affects binding	EXP		6480464	CTD	Hydrocortisone binds to NR3C1 protein	PMID:15705660 PMID:16857225 PMID:11956172
increases activity	EXP		6480464	CTD	Hydrocortisone results in increased activity of NR3C1 protein	PMID:15780662 PMID:21543282 PMID:19672399
multiple interactions	ISO	RGD:10691	6480464	CTD	Fluoxetine promotes the reaction [Hydrocortisone results in increased activity of NR3C1 protein]	PMID:12871829
increases activity	ISO	RGD:10691	6480464	CTD	Hydrocortisone results in increased activity of NR3C1 protein	PMID:12871829
increases activity	EXP		6480464	CTD	Hydrocortisone results in increased activity of NR3C1 protein	PMID:15780662 PMID:19672399 PMID:21543282
affects binding	EXP		6480464	CTD	Hydrocortisone binds to NR3C1 protein	PMID:11956172 PMID:15705660 PMID:16857225
decreases expression	EXP		6480464	CTD	Hydrocortisone results in decreased expression of NR3C1 mRNA	PMID:21267416 PMID:21980503
increases phosphorylation	EXP		6480464	CTD	Hydrocortisone results in increased phosphorylation of NR3C1 protein	PMID:18483179 PMID:21267416
decreases expression	EXP		6480464	CTD	Hydrocortisone results in decreased expression of NR3C1 protein	PMID:21267416