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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732061 Species: Homo sapiens RGD Object: Gene Symbol: CDK4 Name: cyclin-dependent kinase 4

Acc ID: CHEBI:27899 Term: cisplatin Definition: A platinum-containing anticancer drug that interacts with, and forms cross-links between, DNA and proteins. It is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. CasRN: 15663-27-1 Chemical ID: MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Cisplatin results in decreased activity of [CCND1 protein binds to CDK4 protein]	PMID:21592546
decreases expression	ISO	RGD:732062	6480464	CTD	Cisplatin results in decreased expression of CDK4 mRNA	PMID:21151649
multiple interactions	EXP		6480464	CTD	(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane inhibits the reaction [Cisplatin results in decreased expression of CDK4 protein] Cisplatin promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased expression of CDK4 mRNA]	PMID:20195699
decreases expression	EXP		6480464	CTD	Cisplatin results in decreased expression of CDK4 protein	PMID:20195699
decreases expression	ISO		6480464	CTD	Cisplatin results in decreased expression of CDK4 mRNA	PMID:21151649