GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Kcnma1 | decreases expression | ISO | Kcnma1 (Rattus norvegicus) | 6480464 | CTD | Estradiol results in decreased expression of KCNMA1 mRNA; Estradiol results in decreased expression of KCNMA1 mRNA alternative form; Estradiol results in decreased expression of KCNMA1 protein | PMID:16102753 | Kcnma1 | increases activity | ISO | KCNMA1 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased activity of KCNMA1 protein | PMID:18068743 | Kcnma1 | multiple interactions | ISO | Kcnma1 (Rattus norvegicus) | 6480464 | CTD | Fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA alternative form]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 protein] | PMID:16102753 | Kcnma1 | multiple interactions | ISO | KCNMA1 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with Progesterone] results in increased expression of KCNMA1 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of KCNMA1 mRNA; iberiotoxin inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]; Progesterone inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]; Tetraethylammonium inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein] | PMID:18068743 PMID:20660070 PMID:30165855 | |
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