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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731981
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNMA1
Name: potassium calcium-activated channel subfamily M alpha 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNMA1multiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of KCNMA1 mRNAPMID:28628672
KCNMA1multiple interactionsISOKcnma1 (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 mRNA]; Dexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 protein]PMID:15088113
KCNMA1multiple interactionsISOKcnma1 (Mus musculus)6480464CTD[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 mRNA; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with Indomethacin co-treated with rosiglitazone co-treated with Triiodothyronine] results in increased expression of KCNMA1 proteinPMID:27605626
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