GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CACNA2D1 | affects response to substance | ISO | Cacna2d1 (Mus musculus) | 6480464 | CTD | CACNA2D1 protein affects the susceptibility to Methamphetamine | PMID:21182903 | CACNA2D1 | increases expression | ISO | Cacna2d1 (Mus musculus) | 6480464 | CTD | Methamphetamine results in increased expression of CACNA2D1 mRNA; Methamphetamine results in increased expression of CACNA2D1 protein | PMID:20340177 PMID:21182903 | CACNA2D1 | multiple interactions | ISO | Cacna2d1 (Mus musculus) | 6480464 | CTD | [gabapentin binds to and results in decreased activity of CACNA2D1 protein] which results in decreased susceptibility to Methamphetamine; DRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; DRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]; DRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; DRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]; gabapentin inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]; Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; Sulpiride inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein] | PMID:20340177 PMID:21182903 | | ||||||||||||||||||||||
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