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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731712 Species: Homo sapiens RGD Object: Gene Symbol: RB1 Name: retinoblastoma 1

Acc ID: CHEBI:16240 Term: hydrogen peroxide Definition: An inorganic peroxide that has formula H2O2. CasRN: 7722-84-1 Chemical ID: MESH:D006861

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	calyculin A inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of RB1 protein] Okadaic Acid inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of RB1 protein]	PMID:12621062
decreases expression	EXP		6480464	CTD	Hydrogen Peroxide results in decreased expression of RB1 mRNA	PMID:12419474
decreases phosphorylation	EXP		6480464	CTD	Hydrogen Peroxide results in decreased phosphorylation of RB1 protein	PMID:15242773 PMID:12621062
decreases phosphorylation	EXP		6480464	CTD	Hydrogen Peroxide results in decreased phosphorylation of RB1 protein	PMID:12621062 PMID:15242773
multiple interactions	EXP		6480464	CTD	[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RB1 protein	PMID:18951874