RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	731644
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	RPS6KB1
Name:	ribosomal protein S6 kinase, 70kDa, polypeptide 1

Acc ID:	CHEBI:9168
Term:	sirolimus
Definition:	A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
CasRN:	53123-88-9
Chemical ID:	MESH:D020123

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[Dexamethasone co-treated with Sirolimus] inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein] [Dexamethasone co-treated with Sirolimus] inhibits the reaction [IL6 protein results in increased phosphorylation of RPS6KB1 protein]	PMID:15070696
multiple interactions	EXP		6480464	CTD	[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of RPS6KB1 protein	PMID:18622747
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]	PMID:15919668
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [Testosterone results in increased phosphorylation of RPS6KB1 protein]	PMID:21036700
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of RPS6KB1 protein]	PMID:21898527
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [Acetaldehyde results in increased activity of RPS6KB1 protein]	PMID:16962100
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]	PMID:19567381
decreases activity	EXP		6480464	CTD	[Sirolimus results in decreased activity of MTOR protein] which results in decreased activity of RPS6KB1 protein	PMID:14673156
decreases activity	EXP		6480464	CTD	Sirolimus results in decreased activity of RPS6KB1 protein	PMID:17908691
multiple interactions	EXP		6480464	CTD	[Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased activity of IRS1 protein	PMID:17908691
multiple interactions	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein	PMID:15914125 PMID:17616671
multiple interactions	ISO		6480464	CTD	MRK 003 promotes the reaction [Sirolimus results in decreased activity of RPS6KB1 protein] Sirolimus promotes the reaction [MRK 003 results in decreased activity of RPS6KB1 protein]	PMID:19246562
multiple interactions	ISO		6480464	CTD	Sirolimus inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]	PMID:19567381
decreases phosphorylation	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:20682991 PMID:20574048 PMID:15782132 PMID:15070696 PMID:19625624
multiple interactions	ISO		6480464	CTD	Sirolimus inhibits the reaction [Propranolol results in increased phosphorylation of RPS6KB1 protein]	PMID:16537399
multiple interactions	ISO		6480464	CTD	Sirolimus inhibits the reaction [TSC1 gene mutant form results in increased phosphorylation of RPS6KB1 protein]	PMID:18495876
decreases activity	ISO		6480464	CTD	Sirolimus results in decreased activity of RPS6KB1 protein	PMID:19246562
multiple interactions	ISO		6480464	CTD	[Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BAX mRNA [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BID mRNA [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BAX protein [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BID protein	PMID:19922502
decreases phosphorylation	ISO		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:16537399
multiple interactions	ISO	RGD:620683	6480464	CTD	Sirolimus inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein] Sirolimus inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein] Sirolimus inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]	PMID:12411397
multiple interactions	ISO	RGD:620683	6480464	CTD	Sirolimus inhibits the reaction [INS1 protein results in increased phosphorylation of RPS6KB1 protein] Sirolimus results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein	PMID:21357504
multiple interactions	ISO	RGD:620683	6480464	CTD	Sirolimus inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]	PMID:17728140
decreases phosphorylation	ISO	RGD:620683	6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:16391472
decreases phosphorylation	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:19625624 PMID:20574048 PMID:20682991 PMID:15782132 PMID:15070696
decreases phosphorylation	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:15070696 PMID:15782132 PMID:19625624 PMID:20682991 PMID:20574048
multiple interactions	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein	PMID:17616671 PMID:15914125
decreases phosphorylation	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:15782132 PMID:15070696 PMID:20574048 PMID:19625624 PMID:20682991
decreases phosphorylation	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:20682991 PMID:20574048 PMID:15070696 PMID:19625624 PMID:15782132
multiple interactions	ISO	RGD:620683	6480464	CTD	Sirolimus inhibits the reaction [Cadmium results in increased phosphorylation of RPS6KB1 protein]	PMID:21933187
multiple interactions	ISO	RGD:620683	6480464	CTD	Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]	PMID:18021293
multiple interactions	EXP		6480464	CTD	[Sirolimus results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased abundance of Nitric Oxide	PMID:21544240
decreases phosphorylation	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:20682991 PMID:15782132 PMID:15070696 PMID:19625624 PMID:20574048
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]	PMID:21984483
decreases phosphorylation	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:15070696 PMID:15782132 PMID:19625624 PMID:20574048 PMID:20682991
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]	PMID:15297429
decreases activity	EXP		6480464	CTD	Sirolimus results in decreased activity of RPS6KB1 protein	PMID:17908691 PMID:21544240
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]	PMID:22215663
multiple interactions	ISO		6480464	CTD	Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]	PMID:22215663
multiple interactions	ISO		6480464	CTD	Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]	PMID:14516795
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]	PMID:16183647
multiple interactions	EXP		6480464	CTD	[Sirolimus results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein	PMID:20169165 PMID:22574221
decreases phosphorylation	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:15070696 PMID:15782132 PMID:19625624 PMID:20574048 PMID:20682991 PMID:21168265
decreases phosphorylation	ISO		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:16537399 PMID:21321189
decreases phosphorylation	ISO		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:16537399 PMID:20880397 PMID:21321189
decreases phosphorylation	EXP		6480464	CTD	Sirolimus results in decreased phosphorylation of RPS6KB1 protein	PMID:15070696 PMID:15782132 PMID:19625624 PMID:20574048 PMID:20682991 PMID:21168265 PMID:22869613
multiple interactions	EXP		6480464	CTD	Sirolimus inhibits the reaction [Orotic Acid results in increased phosphorylation of RPS6KB1 protein]	PMID:22863860
multiple interactions	EXP		6480464	CTD	Sirolimus promotes the reaction [sodium arsenite results in decreased phosphorylation of RPS6KB1 protein] sodium arsenite promotes the reaction [Sirolimus results in decreased phosphorylation of RPS6KB1 protein]	PMID:22869613
multiple interactions	ISO		6480464	CTD	Sirolimus inhibits the reaction [INS1 protein results in increased phosphorylation of RPS6KB1 protein]	PMID:20880397

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