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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071 Species: Homo sapiens RGD Object: Gene Symbol: AHR Name: aryl hydrocarbon receptor

Acc ID: CHEBI:8069 Term: phenobarbital Definition: Barbituric acid substituted at C-5 by ethyl and phenyl groups. CasRN: 50-06-6 Chemical ID: MESH:D010634

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10127	6480464	CTD	Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]	PMID:17505019
multiple interactions	ISO	RGD:10127	6480464	CTD	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of AHR mRNA]	PMID:19482888
increases expression	ISO	RGD:10127	6480464	CTD	Phenobarbital results in increased expression of AHR protein	PMID:17505019
increases expression	ISO	RGD:10127	6480464	CTD	Phenobarbital results in increased expression of AHR mRNA	PMID:19482888
multiple interactions	ISO	RGD:2074	6480464	CTD	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AHR protein	PMID:20935162
multiple interactions	ISO	RGD:2074	6480464	CTD	Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA] Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]	PMID:17505019
increases expression	ISO	RGD:2074	6480464	CTD	Phenobarbital results in increased expression of AHR mRNA	PMID:19162173 PMID:12011481 PMID:17505019
increases expression	ISO	RGD:2074	6480464	CTD	Phenobarbital results in increased expression of AHR protein	PMID:17505019
increases expression	ISO	RGD:2074	6480464	CTD	Phenobarbital results in increased expression of AHR mRNA	PMID:12011481 PMID:17505019 PMID:19162173
increases expression	ISO	RGD:2074	6480464	CTD	Phenobarbital results in increased expression of AHR mRNA	PMID:19162173 PMID:17505019 PMID:12011481
increases expression	ISO	RGD:10127	6480464	CTD	Phenobarbital results in increased expression of AHR mRNA	PMID:19482888 PMID:21335049
increases expression	ISO	RGD:10127	6480464	CTD	Phenobarbital results in increased expression of AHR mRNA	PMID:19482888 PMID:21335049 PMID:23091169